Development and validation of multi-domain interventions

A major recent accomplishment stands from the development and validation of multi-domain interventions combining physical exercise and cognitive training to improve cognition (Bherer et al., 2020, Desjardins-Crépeau et al., 2016), mobility (Fraser et al., 2017) and walking (Pothier et al., 2018). More recently, we have shown the advantage of combining exercise and cognitive training to improve dual-tasking abilities in older adults (Bherer et al. 2020). The expertise we developed on multi-domain intervention had a significant impact on our national and international collaborations by allowing us to take a leadership role in the Canadian Consortium on Neurogeneration in Aging (CCNA), for which my lab designed fitness training programs and provide iPad-based training platforms in 5 clinical sites across Canada (see Montero-Odasso et al., 2018 for the methodological paper).


  1. Desjardins-Crépeau, L., Berryman, N., Fraser, S., Vu, T.T.M., Kergoat, M.J., Li, K., Bosquet, L. & Bherer, L. (2016). Effects of combined physical and cognitive training on fitness and neuropsychological outcomes in healthy older adults.  Clinical Interventions in Aging. 2016:11 1287-99.
  2. Fraser, S.A., Li, K.Z., Berryman, N., Desjardins-Crépeau, L., Lussier, M., Vadaga, K., Lehr, L., Minh Vu, T.T., Bosquet, L., & Bherer, L. (2017). Does Combined Physical and Cognitive Training Improve Dual-Task Balance and Gait Outcomes in Sedentary Older Adults? Front Hum Neurosci. 2017 Jan 18;10:688. doi: 10.3389/fnhum.2016.00688. eCollection 2016.
  3. Pothier, K., Gagnon, C., Fraser, S.A., Lussier, M., Desjardins-Crépeau, L., Berryman, N., Kergoat, M.J., Vu, T.T.M., Li, K., Bosquet, L, Bherer, L. (2018). A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults. Aging Clin Exp Res. 2018 Aug ; 30(8) : 921-925. Doi : 10.1007/s40520-017-0878-5.
  4. Bherer L., Gagnon, C. Langeard, A., Lussier, M., Desjardins-Crépeau, L., Berryman, N., Bosquet, L., Vu, TTM., Fraser, S., Li, K.Z.H., Kramer, A.F. (2020). Synergistic effects of cognitive training and physical exercise on dual-task performance in older adults. Journals of gerontology. Series B, Psychological sciences and social sciences.2020 Aug 17; gbaa124. Doi: 10.1093/geronb/gbaa124.